CELLIPSE is focusing its R&D effort on developing therapeutic agents that target and regulate the cytoskeleton of the cell.
The cytoskeleton contains two critical components that play a significant role in particular in cancer pathologies :
- the microtubules that enable cell mitosis (division) and therefore promote cancerous cells proliferation and tumor growth in malignant tissues
- the actin filaments that enable cell motility and in cancer tissues promote the metastasis of malignant cells
Overview of role of microtubules in mitois process. Microtubules enable chromosomes splitting and DNA replication. Microtubules are in yellow and chromosomes in blue. During mitosis, microtubules split chromosomes into two identical pairs.
This research effort undertaken by Dr Lafanechère and its team over the past 15 years gives CELLIPSE unique know-how and insight into physiopathological processes orf the cytoskeleton in oncology and other fieds such as Central Nervous System. This in turns allows CELLIPSE to translate hits from High Content Phenotypic Screening assays into Leads that have the potential to become first-in-class drug candidates as exemplified by the LIMINIB program.