Monthly Archives: November 2018

27

Nov
2018

ASH 2018: New data presented on synergistic action of LIMK inhibitors with BCR-ABL TKIs

During the 60th American Society of Hematology Congress held in San Diego, Pr Thorsten Braun will present the work performed by the Leukemia Translational Laboratory at Hopital Saint Louis, Paris, on selective LIM Kinase 1/2 inhibitors for combination treatment of BCR-ABL1 Acute Lymphoblastic Leukemia.

This new data, to be presented on December 2 at 6 PM, includes positive results from in vitro experiments and in vivo models, obtained when combining administration of CEL_Amide with BCR-ABL1 Tyrosine Kinase Inhibitors including nilotinib.

It reinforces the rationale for looking into LIM Kinase inhibition as synergistic therapeutic agents with widely used Tyrosine Kinase Inhibitors, located upstream of the Rho-GTPase pathway.

The abstract of the presentation can be consulted online here: ASH 2018 Presentation.

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